Polypodium leucotomos, the key ingredient in Plesinox 3A

Throughout history, elements of nature have helped protect our immune system and improve our quality of life.

What is Polypodium leucotomos?

Native to tropical and subtropical regions, Polypodium leucotomos is a fern that has been extensively studied for its remarkable properties. Also known as calaguala, this botanical treasure has been utilised for centuries by indigenous communities for its health benefits.

This fern has been cultivated by our own laboratory since 1970. Our cultivation and extraction process guarantee optimal quality and effectiveness: Polypodium leucotomos is grown at specific dates in experimental farms in Guatemala, where it undergoes primary stabilisation through dehydration under controlled conditions. Subsequently, it is sent to Spain where it is processed and standardised in our extraction plant following the EU’s GMP regulations and the highest quality standards.

All extraction and production procedures are exclusive and patented by Asacpharma, ensuring the chemical integrity of all its components.

How to incorporate Polypodium leucotomos into your daily routine

Incorporating this beneficial plant into your daily life is easier than you imagine thanks to Plesinox 3A and its formula based on encapsulated vitamins and natural elements. Include one capsule daily in the morning and another at night in your daily routine.

Warnings and Considerations

Although the benefits of Polypodium leucotomos are well-established, it is essential to highlight the importance of consulting a healthcare professional before incorporating new supplements into your routine.


In ancient times

Polypodium leucotomos was used as a folk remedy to treat numerous diseases such as asthma and heart disease.


We started growing PLA in Guatemala.


In 1983, an immunomodulatory effect was first described.
See reference


We have been using PLE in different pharmaceutical products for over 40 years: Prescription drugs, food supplements and cosmetics. It is a highly effective treatment with multiple benefits.